Vidrop Oral Drops Company Name :
Medical Union Phamaceutical
Vidrop Oral Drops Trade Name :
Vidrop
Vidrop Oral Drops From :
oral solution
Vidrop is a stabilized aqueous solution of vitamin D, (cholecalciferol).

Vidrop Oral Drops Composition :
Each 1 mI (=28 drops) of oral solution contains:
Vitamin D, (cholecalciferol) 2800 IU. (each drop contains100 lU of vitamin D)
Exciptents: polysorbate 20,vitamin E , glycerin , disodium edetate ,
b cydodextrin , purified water.
Vidrop Oral Drops Properties and Action l :
Vitamin D which is effective in there peutic use when given orally is a naturally occurring hormone in humans. being formed from 7 – dehydrocholesterol in the skin as a result of exposure to sunlight (ultraviolet irradiation). it is also obtained in a small quantities from
dietary source such as milk, butter. liver and egg yolks. Vitamin D reguates calcium and phosphate metabolism. its main function being to mediate intestinal calcium absorption by an active transport
mechanism. it also promotes normal bone formation. The minimum daily requirement of vitamin D is 100 – 400 iu depending on age.
Vidrop Oral Drops Pharmacokinetics :
vitamin D is rapidly absorbed from the proximal and distal small
intestine and transported to its main storage sites (liver and adipose
tissue) bound to specific gtobulins Vitamin D, is biotransformed in the liver to 25-hydroxycholecalciferol (25-HCC , calcifediol) which then undergoes further hydroxylation at position 1 in the kidneys to give the active metabolite 1,25-dihydroxycholecalciferol (1.25-DHCC ;calcitriol). Vitarrin D is stored in the body and excreted mainly in the form of inactive glucurorides. it is exaeted both in faeces via the bile and in urine.
Vidrop Oral Drops Indications and Uses :
– Prevention of rickets
– Treatment of all forms and stages of rickets
– Osteomalacia
– Acute postoperative hypoparathyroidism
– Chronic hypoparathyroidism
Vidrop Oral Drops Dosage and Administration :
– Full term infants : 400 IU (= 4 drops) daily in the first year of life starting in week 2-5.
– Preterm infants: 4oo – 800 IU (= 4-8 drops) daily in the first year of lifeTreatment of rickets: Dosage should be individualized on the basis of frequent determinations of serum calcium and bone X-rays.
Florid rickets: 5000 IU (= 50 drops) daily for three weeks.
Vidrop Oral Drops Instructions :
add the required number of drobs to food or drink
Vidrop Oral Drops Restrictions on Use :
To use Vidrop for rickets prevention in infants : hypothyroidism, idiopathic hypercalcaemia, vitamin-D hypersensitivity, to high dose of vitamin-D therapy in adults : skeletal disoroers involving complete immobilization (which increase calcium excretion),
sarcoidosis (Boeck’s disease), acute pulmonary tuberculosis,
immobilization following corrective orthopedic surgery.
Vidrop should not be given by I. V. injection. Concomitant admintration of vitamin D analogues.
Vidrop Oral Drops Precautions :
– caution is required in patients with disturbances of calcium metabolism kidney failure. kidney stones. arteriosclerosis of coronary disease.
– All forms of vitamin D are toxic in high doses. causing a significant
increase i1 calcium absorption. Toxic effects may also occur if doses of1000 – 3000 iu/kg body weight daily are administered over a period of several months
– caution should be exercised in patients receiving treatment with cardiac glycosides since hypercalcemia may lead to arrhythmia in such cases.
– Particular care should be taken to avoid the following :
– Prophylactic: administration of vitamin D in large doses over a period of months or even years without proper monitoring or a specific indication especially in conjunction with calcium and / or vitamin enriched foods (e.g. babyfoods).
– Patients receiving the recommended dose of vidrop for the prevention of rickets or osteomalacia or as a supplement to the nannal diet should avoid other drugs containing vitamin D and vitamin-D enriched foods.
– Particular care should be exercised in the prophyiactic use of vitamin D of preparations in infants receiving vitamin-D enriched baby foods(normally containing 400 IU perdaily portion).
– The recommended dose should be taken regularty but not exceeded.
– Care should be taken for patients receive sufficient dietary calcium regular blood calcium checks should be performed on patients
Vidrop Oral Drops Pregnancy and Lactation :
Vidrop may be taken by women who are pregnant Of breastfeeding at a dosage corresponding to the normal daily requirement. There is clear evidence that doses in excess of the daily requirement represent a risk to the fetus, although this may be outweighed by the therapeuticbenefit to the mother.
Vidrop Oral Drops Adverse Reactions :
in recominended daily allowance adverse effects are very rare; thesemay include mild gastrointestinal symptoms.
Vidrop Oral Drops Interaction :
– colestyramine colestipol and mineral oils may reduce the intestinal absorption of vitamin D and as long an interval as possible (at least 4 hours) should therefore be allowed between ingestion.
– Concomitant administration with thiazide diuretics may lead to hypercalcaemia, possibly necessitating the withdrawal of vidrop.
– phenytoin (and presumably other liver-enzyme inducing agents) may causea reduction in plasma levels of cholecalciferol.
– Corticosteroids may lessen the effect of cholecalciferol.
– Concomitant administration with cardiac gtycosides may result in cardiac arrhythmia.
Vidrop Oral Drops Overdosage :
it vitamin D overdosage exceeds the excretory capacity of the kidneys,calcium deposits may be formed in the kidneys and vascular walls,The signs and symptoms of overdosage are thirst, polyuria, loss of appetite, nausea, vomiting, constipation, headache, joint pain, muscle weakness, dehydration (especially wizened, dry skin in children),trem of affecting the extremities, muscular atrophy with fibrillary contractions and hypertension these symptoms are reversible provided vitamin D is withdrawn in time.
Vidrop Oral Drops Othr Informations :
note like all drugs vidrop should be kept outof reach of children.
Vidrop Oral Drops Shelf Life :
the drug should not be used after the expiry date (=EXP) printed 00 the pack
Store oral solution at a temperature not exceeding 30°C, away from
light.
Vidrop Oral Drops Pack :
Carton box containing glass bottle type HI of 10 or 15 mt with plastic
dropper with white cap and off/white rubber pump and inner leaflet
Vidrop Oral Drops Produced by :
Medical Union Pharmaceuticals
Abu Sultan, Ismailia, Egypt.