TOXIC GOITRE
" the fire which burn itself "
Aetiology:
Often precipitated by some abnormal stress e.g. psychic trauma, A cute infections, pregnancy and labour
It was thought that failure of adaptation to stress ® abnormal T.S.H secretion. But recent studies showed that T.S.H is suppressed in most cases.
Recently the accepted theory is that there is an antibody to certain thyroid antigens called long-acting thyroid stimulator L.A.T.S. (IgG). Its action on thyroid is similar to T.S.H but has long duration.
Pathology:
Macroscopically: Symmetrical enlargement
Smooth surface.
Firm in consistency.
Highly vascular
Microscopically: The acini increase in number but decrease in size.
Lined with tall columnar cells with papillary projections into the lumen.
The stroma is very vascular and contains an excess of lymphocytes.
SOURCE: Prof. AYMAN SALEM'S BOOK
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