Composition: CILOSTAZOL 50 MG

DRUG CLASS AND MECHANISM: Cilostazol is a medication for the treatment of intermittent claudication, a condition caused by narrowing of the arteries that supply the legs with blood. Patients with intermittent claudication develop pain when they walk because not enough oxygen-containing blood reaches the active leg muscles. Cilostazol reduces the pain of intermittent claudication by dilating the arteries, thereby improving the flow of blood and oxygen to the legs. (It does this by decreasing the action of an enzyme, phosphodiesterase III.) It also reduces the ability of blood to clot. Cilostazol enables patients with intermittent claudication to walk longer and faster before developing pain. Cilostazol has a different mechanism of action than pentoxifylline (Trental), the other drug approved for intermittent claudication. (Pentoxifylline improves blood flow by making it easier for red blood cells to pass through vessels. It also decreases the viscosity of blood.). The FDA approved cilostazol in January 1999.

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PRESCRIBED FOR: Cilostazol improves walking speed and walking distance among patients with intermittent claudication. It does not cure intermittent claudication. Cilostazol has not been studied in patients with leg pain at rest, leg ulcers due to reduced flow of blood, gangrene or rapidly progressing claudication.

A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.
Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Very common: More than 1 in 10 people who take Cilostazol

  • abnormal stools
  • diarrhoea
  • headaches

Common: More than 1 in 100 people who take Cilostazol

  • angina
  • chest pain
  • easy bruising or bleeding problems - some of these bleeding problems may be fatal. Seek immediate medical advice if you bruise easily, bleed from any part of the body, or have blood in your urine
  • faster heart rate
  • feeling dizzy
  • flatulence
  • heart rhythm problems
  • indigestion
  • itching
  • loss of appetite
  • nausea
  • oedema such as oedema of the extremities or facial oedema
  • palpitations
  • pharyngitis
  • rhinitis
  • skin rash or rashes
  • sore throat - seek immediate medical advice if this occurs
  • stomach pain
  • vomiting
  • weakness

Uncommon: More than 1 in 1000 people who take Cilostazol

  • a drop in blood pressure on standing or sitting up
  • allergic reactions
  • blood and bone marrow problems - some of these may be fatal
  • breathing difficulties
  • chills
  • cough
  • diabetes
  • difficulty sleeping
  • eye or eyesight problems - seek immediate medical advice if you have any eye or eyesight problems
  • fainting or brief loss of consciousness
  • feeling anxious
  • gastritis
  • general feeling of being unwell
  • heart attack
  • heart problems
  • increased blood sugar levels
  • muscle pain or tenderness
  • nose bleed
  • pneumonia
  • strange dreams

Rare: More than 1 in 10,000 people who take Cilostazol

  • changes in blood clotting time
  • kidney problems

The frequency of these side-effects is unknown

  • abnormal laboratory test results
  • blood in the urine
  • blood pressure changes
  • eczema
  • fever - seek medical advice if you get a fever
  • hot flushes
  • hypoaesthesia
  • jaundice
  • liver problems
  • lung problems
  • pain
  • paresis
  • skin problems
  • Stevens-Johnson syndrome
  • tinnitus
  • toxic epidermal necrolysis
  • urinating more often
  • urticaria

Cilostazol - Wikipedia, the free encyclopedia
Side effects of cilostazol - Circulation disorders - NHS Choices