Diabetic Atherosclerosis with photos videos 080313124430.jpg

Diabetic Atherosclerosis with photos videos images?q=tbn:ANd9GcQHsh2HU1gn9ZKg5VYmGAOlmjnNBzE94-Yw0ArgXwkjkQt-ah4DNM5WrHGM3w

Diabetic Atherosclerosis with photos videos images?q=tbn:ANd9GcTOF8pW1vhdYVOw4Q6QpiGjSOXuiQGXFBSPQ1UQ3XQpGHBtNoJ-wbsnijSRAA

Atherosclerosis is the deposition of plaques of a mixture of lipid, and fibrovascular
tissue (atheroma) on the inside of the vessel wall of the large blood vessels. Once
established these plaques usually slowly increase in size with two important clinical
consequences:
1. Chronic ischaemia. (Coronary heart disease and peripheral vascular disease)
As the atheromatous plaques get bigger the lumen of the blood vessel gets narrower.
Over time the total blood flow along the affected vessel is gradually reduced leading to
ischaemia of the tissue it supplies. This is the pathological process behind the
development of coronary heart disease and peripheral vascular disease.
eg.
Coronary heart disease. At rest the narrowed blood vessel may be
able to deliver enough blood to satisfy the requirements of the
myocardium (muscle of the heart), but as soon as the patient
starts to exercise the narrowed blood vessel can no longer supply
the myocardium all the blood it demands and the myocardium
becomes ischaemic. The patient experiences this process as chest
pain “angina”.
2. Acute vessel ischaemia (Myocardial infarction)
Atheromatous plaques may rupture. Plaque rupture activates the bodies intrinsic
clotting system, which forms a blood clot over the rupture site. This clot may
completely block the affected vessel leading to acute ischaemia and cell death of all the
tissues supplied by that vessel. Plaque rupture in the coronary vessels is the
commonest cause of acute myocardial infarction (heart attack).

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