Neo-Cortef (discontinued in the UK)

How does it work?

Hydrocortisone belongs to a group of medicines known as corticosteroids. These act inside the cells to decrease the release of certain chemicals that are important in the immune system. These chemicals normally cause itch and inflammation. By decreasing the release of these chemicals in a particular area, itch and inflammation are reduced.

Neomycin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria. Neomycin binds to components in the bacterial cell which result in the production of abnormal proteins. These proteins are necessary for the bacteria's survival. Therefore the production of these abnormal proteins is ultimately fatal to the bacteria.

Hydrocortisone with neomycin is commonly used as drops or ointment for the short-term treatment of inflammation and infection of the eye (blepharitis) or the outer part of the ear canal (bacterial otitis externa). This combination may also be used as an anti-inflammatory in conditions where an antibiotic is also required to prevent infection.
What is it used for?

  • Bacterial infection of the outer ear canal (bacterial otitis externa)
  • Bacterial infections of the eye
  • Red, swollen and painful eyes

  • Consult your doctor if after seven days of treatment with this medicine there is little or no improvement in your symptoms.
  • If this eye preparation is to be used repeatedly, regular eye examinstions are required.
  • This medicine may cause your vision to blur temporarily after you have applied it into your eye. Do not drive or operate machinery until this has worn off.
  • Prolonged use of topical corticosteroids (including eye/ear/nose preparations) or application to large areas of skin, can result in sufficient absorption of the corticosteroid into the bloodstream to prevent the normal production of natural steroid hormones by the adrenal glands (adrenal suppression). This is more likely to occur in infants and children. Consult your doctor or pharmacist for further information.
Use with caution in

  • Decreased kidney function
  • Impaired hearing
  • Infants and elderly
  • Undiagnosed red eye (eye preparations only)
Not to be used in

  • Glaucoma (eye preparations only)
  • Known sensitivity or allergy to any ingredient
  • Non-bacterial eye infections (e.g. fungal) - eye preparations only
  • Perforated ear drum (ear preparations only)
  • Viral infections of the eye (herpes simplex) - eye preparations only
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
  • The safety of this medicine during pregnancy and breastfeeding has not been established. Seek medical advice from your doctor.
Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
  • Irritation in area of use
  • Local sensitivity reactions
  • Stinging or burning at the area of application
  • Increased pressure within the eye (eye preparations only)
  • Visual disturbances (eye preparations only)
  • Itching at the area of application
  • Skin rash at the area of application (local dermatitis)
  • Tear of the eye covering due to the presence of another eye disease (eye preparations only)
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?

No reported significant interactions.