INDICATIONS:

TOBRIN(tobramycin ophthalmic ointment) 0.3 % is a topical antibiotic indicated in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany the use of TOBRIN (tobramycin ophthalmic ointment) 0.3%. Clinical studies have shown tobramycin to be safe and effective for use in children.
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DOSAGE AND ADMINISTRATION:

In mild to moderate disease, apply a half-inch ribbon into the affected eye(s) two or three times per day. In severe infections, instill a half-inch ribbon into the affected eye(s) every three to four hours until improvement, following which treatment should be reduced prior to discontinuation.

How to Apply TOBRIN (tobramycin ophthalmic ointment) 0.3%:

Tilt your head back.
Place a finger on your cheek just under your eye and gently pull down until a ‘‘V'' pocket is formed between your eyeball and your lower lid.
Place a small amount (about 1/2 inch) of TOBRIN (tobramycin ophthalmic ointment) 0.3 % in the ‘‘V'' pocket. Do not let the tip of the tube touch your eye.
Look downward before closing your eye.

SIDE EFFECTS:



The most frequent adverse reactions to TOBRIN (tobramycin ophthalmic ointment) 0.3% are hypersensitivity and localized ocular toxicity, including lid itching and swelling, and conjunctival erythema. These reactions occur in less than three of 100 patients treated with TOBRIN (tobramycin ophthalmic ointment) 0.3%. Similar reactions may occur with the topical use of other aminoglycoside antibiotics. Other adverse reactions have not been reported from TOBRIN (tobramycin ophthalmic ointment) 0.3% therapy; however, if topical ocular tobramycin is administered concomitantly with systemic aminoglycoside antibiotics, care should be taken to monitor the total serum concentration. In clinical trials, TOBRIN (tobramycin ophthalmic ointment) 0.3% produced significantly fewer adverse reactions (3.7%) than did GARAMYCIN® Ophthalmic Ointment (10.6%).

CONTRAINDICATIONS


TOBRIN(tobramycin ophthalmic ointment) 0.3% is contraindicated in patients with known hypersensitivity to any of its components.