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Home Ophthalmology

Optic Neuropathy

Prof.Dr.Gehad Elnahri by Prof.Dr.Gehad Elnahri
May 11, 2020
in Ophthalmology
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Optic Neuropathy

Optic Neuropathy

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1 We discussed previously how to spot optic nerve affection in subtle eye disease and in normal fundus with drop of vision,
2 So clinically “a patient with a drop of vision, lost color vision and a RAPD has an optic neuropathy and if the disc looks normal, a retrobulbar neuropathy” What next?
3 To arrive at the diagnosis of the cause, the history/clinical exam/patient’s demography are very important

One of the difficult clinical situations is optic nerve disease collectively called Optic Neuropathy

Many did not care to differentiate causes of optic neuropathies because there were very few treatment options for optic nerve disease

Optic Neuropathy
Optic Neuropathy

Nowadays many forms of optic neuropathy are treatable as we will point out which makes the differentiation of optic neuropathies more and more important.

We discussed previously how to spot optic nerve affection in subtle eye disease and in normal fundus with drop of vision,

so first lets summarize again:
1)drop of vision is the hallmark, there are mild neuropathies with 6/6 vision though.
2)color desaturation or loss.
3)RAPD in asymmetrical affection.
4)Field defects.
5)VEP.
6)normal photostress test.
7)other less commonly used tests.

So clinically “a patient with a drop of vision, lost color vision and a RAPD has an optic neuropathy and if the disc looks normal, a retrobulbar neuropathy”
What next?

1)if the fundus is NORMAL this is retrobulbar neuropathy and is MS until proved otherwise
Your patient is usually in her (more) or his 20’s or 30’s.
An MRI is mandatory for early diagnosis and treatment of MS by immediate pulse steroids
If the fundus is normal but the loss is bilateral and profound remember to extend the MRI to the cervical region and to ask for anti aquaporin-4 Ab to diagnose NMO-related disease, immediate pulse steroids /immunosuppressors/plasmapharesis.
2)if the disc is SWOLLEN the chances of demyelination decrease and MRI is less urgent.
What should we think about:
-idiopathic ON
-mitochondrial ON (Leber’s)
-toxic ON
-Inflammatory ON
-infiltrative ON
-ischemic ON
-neuroretinitis
-papillophlebitis

To arrive at the diagnosis of the cause, the history/clinical exam/patient’s demography are very important

1)Vitreous cells; this wonderful clinical sign immediately pinpoints inflammatory ON as in Behcet’s disease with marvelous response to steroids. ALWAYS look for vitreous cells.
2)History of Alcohol/Drug intake— remember methyl alcohol in males with pale swollen discs and acute loss of vision for immediate dialysis.
3)Systemic diseases that may cause ON infiltration as leukemias, lymphomas and sarcoidosis.
4)Pale swollen discs above 50 yrs are ischemic optic neuropathies; arteritic or non-arteritic.
5)Swollen discs in teen males with no drug history, systemic disease or vitreous cells are Leber’s ON.
6)Neuroretinitis; swollen disc with macular hard exudate–treat with azithromycin if cat scratch disease is suspected.

Tags: optic neuropathy
Prof.Dr.Gehad Elnahri

Prof.Dr.Gehad Elnahri

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