Neurorubine Ampoules Composition :
Each ampoule contains:
Vitamin Bl (USP) 200 mg
Vitamin B6 (USP) 50 mg
Vitamin B12 (USP) 1000 mcg
Lidocaine HC! 10 mg
Each Lactab contains:
Vitamin Bl (USP) 200 mg
Vitamin B6 (USP) 50mg
Vitamin B12 (USP) 1000 meg
Neurorubine Ampoules Properties and effects :
Neurorubine combines in high doses three vitamins which are indispensable in the nervous system. Thiamin (Vitamin Bl) plays an important role as a co-enzyme in several metabolic pathways of carbohydrates alcohol and aminoacids. Neurons require chemical respiratory activities to produce energy and proper structure of neurons maintenance derived from the oxidation of carbohydrate mostly. This lmportant and essential role of thiamin in the breakdown of carbohydrate proved how its deficiency feads to a biochemical neuronal damage. In chronic or acute cases of deficiency of thiamin it is possible to observe neuropatic clinical syndrome, a wide range from Beriberi through Wernicke’s encephalopathy, Korsakoff’s disease up to alcoholic polyneuropathy.
Pyridoxine (Vitamin B6) acts into the aminoacid. carbohydrate and fat metabolisms and it is also required for hemoglobin production. Pyridoxine deficiency due to inadequate dietary intake, absorption interference or drug interactions, leads to peripheral neuritis in adults and pyridoxine’s deficiency can affect the CNS development in children.
Cobalamin (Vitamin B 12) as all other vitamins, is essential for the proper cellular biochemical functions. Vitamin B12 main functions are the cellular replication and growth. Vitamin B12 deficiency is clinically recognized by the negative clinical impact in both nervous and hematopoietic systems. In the first case it can be seen progressive damage of the nervous system like swelling of myelinated neurons, demyelinization, degeneration of spinal cord
and cerebral cortex. This causes a broad range of neurological signs and symptoms like paresthesia, diminished sensation of vibration and position, reluctant unsteadiness, depressed tendon reflexes, loss of memory, confusion moodiness and loss of central vision (retinopathy), delusions, hallucinations or even psychosis. There are different mechanisms of action for B-vitamins in the pain process. These B-vitamins are co-enzymes in several metabolic pathways in the nervous system They play an important role in inflammatory and edematous neuronal processes; impaired axons impulse transmission; abnormal high excitability of neurons in peripheral and central nervous system; synthesis of inhibitory neurotransmitters There are several clinical experiences and experimental evidences on the therapeutic use of the pharmaceutical combination of these three B-vitamins to revert neuralgi syndromes and the interference in the genesis of compressive, rheumatic and degenerative pains.
Neurorubine Ampoules Indications :
. Diabetic polyneuropathies.
. Neuralgic pain of varying origin (trigeminal neuralgia, intercostal neuralgia, sciatalgia, herpes zoster)
. Acute or chronic neuritis and polyneuritis.
. Optic neuritis.
. Toxic damage to the nerve tissue (alcoholism and drugs. chemical or physical intoxications)
. Neuromuscular pain, tremors, cramps.
. Rheumatic pain.
. Coadjuvant in the treatment of migrain or peripheral vascular disorders.
. Asthenia. convalescence and major surgery procedures.
. Neurological consequences of multiple sclerosis and different types of anaemias.
Neurorubine Ampoules Recommended dosage :
The dosage should be adapted to individual patients. Severe Cases: At the beginning of treatment and until the pain disappears. one ampoule every day or every second day by intramuscular injection. Subsequently, one ampoule once or twice a week. Standard treatment: One ampoule once or twice a week.
The dosage should be adapted to each individual case: 1 -3 Lactab daily.
Severe cases: Treatment to be commenced with 4 Lactab daily until the pain
Neurorubine Ampoules Drug Interaction :
The effect of levodopa is diminished by vi- tamin 86.
Neurorubine Ampoules Pregnancy. lactation :
Neurorubine-Forte may be taken during pregnancy and lactation. Controlled studies in women have shown no risks to the foetus during the first trimester; there is no evidence suggesting a risk in the course of the remaining trimesters.
Neurorubine Ampoules Contraindications :
Neurorubine is contraindicated in patients with known hypersensitivity to vitamin 81. 86. or 812
Neurorubine Ampoules Technique of Injection :
The intramuscular injection should be made preferably in the upper and outer
portion of the gluteal muscle. If properly administered, the injection is painless.
Neurorubine Ampoules Presentations :
Neurorubine I Ampoules
Packings of 3 ampoules of 1 ml Neurorubine I – Forte Lactab I
Packings of 20 lactab
Neurorubine Ampoules Manufactured by :
Medical Union Pharmaceuticals
Under Supervision of Mepha Ltd, Basel, Switzerland
Alepha Pharma Egypt S.A.E.