Longicef capsules Properties:
It is a semisynthetic Cephalosporin antibiotic for oral administration.
It is highly stable in the presence of beta – lactamase enzymes.
It has been shown to be active against most
strains of the following organisms:
– Gram-positive organisms. Streptococcus pneumoniae, Streptococcus pyogens.
– Gram-negative. Escherichia coli. Klebsiella pneumoniae, Haemophilus influenza, Salmonella & Shigella species.
Longicef capsules indications and usage:
It is indicated in the treatment of acute bronchitis, otitis media, pneumonia, lung abscess, skin and soft tissue infections & urogenital infections like pyelitis, pyelonephritis, vulvovaginitis … etc.
Longicef capsules side effects:
Side effects are mild & transient, those reported include:
– Gastrointestinal events: diarrhea, nausea & vomiting.
– Hypersensitivity reactions: skin rash, urticaria.
– Transient elevation in serum transaminases.
– With prolonged use of LONGICEF, monilia vaginitis and rarely pseudomembranous colitis may occur.
Longicef capsules contraindications:
History or suspected hypersensitivity to cephalosporins. In patients hypersensitive to penicillins (cross allergy). Longicef should be used with caution in person with history of severe allergies or asthma.
Longicef capsules Warnings and Precautions :
– Careful inquiry should be made for previous hypersensitivity reactions to Cephalosporins, Penicillins or other drugs.
– Prolonged use of an anti-infective may result in overgrowth of non-susceptible organisms e.g. fungi as candida.
– It should be prescribed with caution to individuals with a history of gastrointestinal diseases particularly colitis.
– Safety for use during pregnancy has not yet been established.
– Symptoms of vitamin K deficiency( hernorrhage) or vitamin B deficiency (stomatitis, glossitis, neuritis, anorexia, etc … ) can occur with prolonged treatment with it.
Longicef capsules drug interactions:
– Treatment with Longicef in combination with arninoglycoside antibiotics, polymtxin B or high dose loop diuretics should be avoided since such combinations can potentiate the nephrotoxic effects.
Frequent check on coagulation parameters are necessary when cephalosporins (high doses) are given with anticoagulants to avoidhemorrhagic complications.
– It may attenuate the effect of oral contraceptives
Longicef capsules dosage and administration: (Orally)
It is better to take it with food.
– LONGICEF Capsules 500 mg/capsule Adults & Children over 12 years: 1-2 capsules twice daily. Children over 6 years: 1 capsule twice daily.
– LONGICEF Suspension 125 mg/5ml Children below 1 year: 25 mg I kg daily in 2 divided doses. Children 1 – 6 years: 2 teaspoonfuls twice daily
– LONGICEF Suspension 250 mg/5ml Children 1 – 6 years: 1 teaspoonful twice daily. Children over 6 years: 2 teaspoonfuls twice daiJy.
Longicef capsules reconstitution:
Longicef 125 mg & 250 mg suspension to make up to 60 ml, first invert bottle & shake powder loose, then add 40 ml of boiled cooled water in 2 portions.
shaking after each addition until a homogenous suspension is achieved .Shake well before use.
Capsules. each capsule contains 500mg cefadroxil.
Granules for oral suspension 125 mg/ 5ml.
Granules for oral suspension 250 mg/5ml .
After reconstitution of contents according to label.
After reconstitution refrigerate for 14 days, discard after 14 days.
– Plastic container contains 33 gm granules (constituted to 60 ml with water).
– Boxes of 8 capsules (J strip x 8 capsules).
Capsules: Store at ( 15 – 25· C ). away from light & humidity.
Granules .Store atatcmperature not exceeding 30 C, protected from light & humidity.
Produced by :
KARlRA PHARM. & CHEM. IND. CO.
CAIRO – EGYPT.