Flumox capsules composition:
Each vial 500 mg contains:
Amoxycillin (as sodium salt) 250 mg; Flucloxacillin (as sodium salt) 250 mg.
Each vial 1000 mg contains:
Amoxycillin (as sodium salt) 500 mg; Flucloxacillin (as sodium salt) 500 mg.
Flumox capsules properties:
It is a combination of two bactericidal penicillins: amoxycilin (broad-spectrum penicillin) and flucloxacillin (penicillinase-resistant penicillin), to produce a wider spectrum of activity. Flucloxacillin exerts a bactericidal action on penicillinase -producing microorganism including most staphylococci.This combination exhibits bactericidal activity against a wide range of Gram-positive and Gram-negative microorganisms including penicillinase and non penicillinase – producing Staphylococci, Streptococcus pyogenes, pneumoniae, and faecalis, Corynebacterium diphtheriae, Clostridia spp., Bacillus anthracis; H.influenzae, Moraxella (Branhamella) catarrhalis, N.gonorrheae and meningitidis, E.coli, Proteus mirabilis, Salmonella, Bordetella pertussis. and Bacteroides melaninogenicus.
Flumox Capsules Pharmacokinetics:
FLUMOX® (amoxycillin sodium and flucloxacillin sodium) vial is given by injection; peak plasma concentrations are achieved in about 30 minutes following intramuscular injection. Doupling the dose can double the plasma concentrations. It is widely distributed at varying concentrations in body tissues and fluids. It is metabolized to a limited extent and the unchanged drug and metabolites are excreted in the urine and bile within 6 – 8 hours.
Flumox capsules indications:
It is indicated in the treatment of a wide range of infections including:
Respiratory tract infections: Bronchitis, pneumonia and emphysema.
Ear, nose and throat infections: Otitis media, sinusitis, tonsillitis and pharyngitis
Gastro-intestinal tract infections: Enteritis, cholecystitis, typhoid and paratyphoid fever. Genito- urinary tract infections: Cystitis, pyelonephritis, prostatitis, gonorrhea, and puerperal sepsis.
• Skin and soft-tissue infections: Boils, carbuncles, abscesses, cellulitis, post-operative
wound infections, and intra-abdominal sepsis.
Bone infections: Osteomyelitis and septic arthritis.
Other infections: Septicaemia, endocarditis, peritonitis
, biliary tract infections, and meningitis.
Flumox capsules dosage and administration:
Adults: 0.5g • 1 g. every 6 – 8 hours.
Children: (2 -12 years):1/2 adult dose; children (less than 2 years):1/4 adult dose.
• Administration may be intramuscular, intravenous injection or infusion.
In severe infections, the vial may be given in infusion, every 4 – 6 hours.
For intramuscular injection, FLUMOX® vial 500 mg should be dissolved in 2 ml;
FLUMOX® vial 1000 mg should be dissolved in 4 ml of water for injection.
For intravenous injection, FLUMOX® vial 500 mg should be dissolved in 5 ml; but
FLUMOX® vial 1000 mg should be dissolved in 10 rnl of water for injection, given slowly over 3 – 4 minutes.
It should be injected immediately after reconstitution with distilled water.
It is stable with the commonty- used intravenous fluids at 25 C, if infused over a maximum period of 6 hours.
• Solutions containing dextrose or other carbohydrates should be infused within
30 • 40 minutes and must be changed within 2 hours. Solutions containing sodium bicarbonate must be changed within 4 hours. It must not be mixed with blood products or proteinaceous fluids.
Flumox capsules precautions:
Doses should be reduced in severe renal impairment.
Flumox capsules contra-indications:
A known hypersensftivity to penicillins.
Flumox capsules side effects :
As with other penicillins, side-effects are usually mild and transient including diarrhoea, indigestion and skin rashes.
FLUMOX® Vial 500 mg : Boxes of 1 or 50 or 100 vials each.
FLUMOX® Vial1oo0 mg : Boxes of 1 or 50 or 100 vials each.
Also available :FLUMOX® Capsules: 250 mg and 500 mg.
FLUMOX® Dry Mix : 250 mg/5ml .
IKeep out ach of children .To be used under medical supervision.
Produced by :
EGYPTIAN INT. PHARMACEUTICAL INDUSTRIES CO.
TENTH OF RAMADAN CITY A. R. E.