Flexofan Capsules Company name :
Amriya Pharmaceutical ind.
Flexofan Capsules Trade name :
Flexofan Capsules
Flexofan Capsules Generic Name :
Ketoprofen
Chlorzoxazone
Flexofan
Capsules Composition :
Each capsule contains:
Active Ingredients:
Ketoprofen 50 mg
Chlorzoxazone 250 mg
Flexofan Capsules Inactive Ingredients:
Croscarmellose sodium. Calcium phosphate tribasic (anhydrous). Magnesium stearate. PVP k25 Sodium hydroxide
Flexofan Capsules Pharmaceutical Form :
Oral capsules
Flexofan Capsules Pharmacology :
ChlorzoxlfZone IS a centrally acting skeletal muscle relaxant wittrs edative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. Its effects begin within an hour of an oral dose and last for 3 to 4 hours. Ketoprofen. a propionic acid derivative is an NSAID.
Flexofan Capsules Pharmacokinetics :
Chlorzoxazone is readily absorbed from the gastrointestinal tract and metabolized in the liver. Chlorzoxazone is primarily excreted in urine. Its half life is 1.1 hours. Ketoprofen is readily absorbed from the gastrointestinal tract; peak plasma concentrations occur about 0.5 to 2 hours after an oral dose. Ketoprofen is 99% bound to plasma proteins and substantial concentrations of drug are found in the synovial fluid. The elimination half-life in plasma is about 1.5 to 4 hours. Ketoprofen is metabolised mainly by conjugation with glucuronic acid. and is excreted mainly in the urine.
Flexofan Capsules Indications :
Flexofan is used as an adjunct in the symptomatic treatment of painful muscle spasm associated with musculoskeletal conditions.
Flexofan is also used in the treatment of pain and mild inflammation in rheumatic disease and othermusculoskeletal disorders, and after orthopaedic surgery and acute gout.
Flexofan Capsules Dosage and Administration :
1 capsule 3 – 4 times daily.
The total dose should not exceed 6 capsules daily in divided doses.
Flexofan Capsules Contraindications :
– Hypersensitivity to any of the components.
– Bronchospasm
– Peptic ulceration
– Severe renal insufficiency
Flexofan Capsules Side effects :
Drowsiness, fever, headache, nausea, vomiting, stomach cramps, rash and pancreatitis. Photosensitivity reactions and cross-sensitivity to other drugs, notably bezafibrate, ciprofibrate and fenofibrate.
Flexofan Capsules Drug Interactions :
The C.N.S effect of chlorozoxazone may be enhanced by alcohol and C.N.S depressants. Disulfiram reduced plasma clearance of chlorzoxazone. Ketoprofen is highly protein bound. In theory, interaction is possible following the concomitant use of other protein- bound drugs, for example, anticoagulants, sulfonamides, and hydantoins. The mode of action of non-steroidal anti-inflammatory drugs in causing a hazardous interaction with methotrexate is not certain, but may be via inhibition of the tubular secretion of methotrexate. Ketoprofen slightly inhibits the sodium diuresis induced by furosemide. Lithium intoxication has been reported as a result of concurrent administration of ketoprofen. Probenecid increases the concentration of ketoprofen and of ketoprofen conjugates.
Nonsteroidal anti inflammatory drugs (NSAIDS) PPT power point presentation :
Flexofan Capsules