Fladazole tablets Composition :
Each tablet contains:
Secnidazole 500 mg.
Fladazole tablets properties :
Secnidazole is a 5-nitroimidazole derivative. It has antiparasitic activity against Entameba histolytica, Trichomonas vaginalis and Giardia lamblia.
Fladazole tablets pharmacokinetics :
It is readily absorbed after administration by mouth. Peak plasma concentrations are achieved within 3 hours after a single oral dose of 2 gm (4 tablets). It is mainly eliminated in urine. Plasma half-life is about 24
hours.
Fladazole tablets Indications :
– Intestinal amebiasis
– Hepatic amebiasis
– Urogeoital Urichomooiasis
– Giardiasis
Fladazole tablets contraindications :
History of hypersensitivity to imidazole derivatives Pregnancy or lactation .
Fladazole tablets side effects :
Occasionally, it may cause some G.IT. disorders, e.g. nausea, vomiting, abdominal cramps and an unpleasant metallic taste. In rare cases, moderate leucopenia may occur which disappears after treatment discontinuation.
Fladazole tablets precautions :
– Avoid administration with patients who had blood dyscrasias.
– Avoid alcohol consumption during treatment with secnidazole.
Fladazole tablets drug interactions:
– Do not associate with disulfiram as it may lead to delirium or mental confusion.
– Adjust oral anticoagulant dosage during secnidazole treatment
Fladazole tablets dosage :
Acute intestinal amebiasis: 1-day treatment
Adults: 2 gm (4 tablets) as a single dose.
Children: 30 mg/kg in a single dose.
Chronic intestinal amebiasis (cystic form): 3-day treatment
Adults: 2 gm (4 tablets) in a single daily dose for 3 days.
Children: 30 mg/kg in a single daily dose for 3 days.
Hepatic amebiasis: 5-day treatment
Adults: 1.5 gm (3 tablets) in a single daily dose for 5
Children: 30 mg/kg in a single daily dose for 5 days. Urogenital trichomoniasis: 1-day treatment
Adults: 2 gm (4 tablets) as a single dose.
Giardiasis: 1-day treatment.
Adults: 2 gm (4 tablets) as a single dose.
Children: 30 mg/kg in a single dose.
N.B.:
To take the tablets at the beginning of the meal.
How Supplied :
Strips of 4 tablets in packs of 1 strip.
Keep all medicaments out of reach of children
Product of:
AMOUN PHARMACEUTICAL CO. SAE.
EI-Obour City, Cairo, Egypt.