Bronchophane syrup composition:
Each 5 ml contains:
Guaiphenesin 50 mg
Ephedrine hydrochloride 7.5 mg
Diphenhydramine hydrochloride 5 mg
Dextromethorphan hydrobrorrude 6.25 mg
Bronchophane syrup excipients:
: Sodium phosphate dibasic, citric acid anhydrous. sucrose, sorbitol 70%, sodium benzoate, FOC yellow no.6, peach flavor, propylene glycol, ethanol, purified water.
Bronchophane syrup properties:
It is a well-tolerated balanced formula acting as expectorant and cough sedative. It contains guaiphenesin, ephedrine hydrochloride, diphenhydramine hydrochloride. and dextromethorphan hydrobromide. Guaiphenesin increases production of respiratory tract fluids to help liquefy and reduce viscosity of tenacious sputum. It thins respiratory secretions for easier removal. If sputum is not removed, it may support growth of bacteria and make breathing more difficult. Ephedrine is a sympathomimetic ( with direct and indirect effects on adrenergic receptors ) causes bronchodilatation, thus relieving bronchospasm and nasal congestion. Diphenhydramine is a sedating antihistamine. It is used for the symptomatic relief of allergic conditions including rhinitis. It has pronounced central sedative properties and is a common ingredient of compound preparations for symptomatic treatment of coughs and common cold. Dextromethorphan is a cough suppressant used for the relief of non-productive cough; It has a central action on the cough centre in the medulla. Bronchophane does not completely suppress the cough but calms it without influencing the expectorant property of quatphenestn. Consequently, It provides a full range of therapeutic action against the cough, promoting tracheobronchial secretion, relieving bronchospasm in asthmatic bronchitis, besides being helpful to control distressing coughs
Bronchophane syrup indications:
-Acute and chronic bronchitis
-Cough associated with common cold.
Bronchophane syrup dosage and administration:
Unless prescribed by the physician the dose as follows:
Children more than 6 years: 1/2 teaspoonful 3 – 4 times daily.
Adults: 1-2 teaspoonful 3 times daily.
Bronchophane syrup drug interactions:
CNS depressants and alcohol: May increase sedation.
MAO inhibitors: May cause severe hypertension. Do not use together.
Antihypertenstves: it may decrease their effects.
Bronchophane syrup precautions:
It should be used with caution in:
– Elderly patients.
– Hypertension and hyperthyroidism.
– Nervous or excitable states, diabetes, or prostatic hyperplasia.
Bronchophane syrup pregnancy and lactation:
It should not be used during pregnancy and it is not recommended during lactation.
Bronchophane syrup contraindications:
-Hypersenstivity to the drug and other sympathomimetic drugs.
-Patients taking monoamine oxidase inhibitors (MAOls, cerratn drugs prescribed for depression, psychiatric, or emotional conditions, or Parkinson’s disease or within 2 weeks of stopping MAOls.
-Severe coronary artery disease or cardiovascular disease.
-It is contraindicated in children less than 6 years old.
-It is contraindicated in pregnant women, patients with renal or hepatic impairment, and in patients treated with metronidazole or disulfiram, because of the potential risk of toxicity from the large amount of the excipient propylene glycol.
Bronchophane syrup side effects:
The side effects may include drowsiness, sedation, and headache.
store at atemperature not exceeding 30 c away from light
Produced by :
Egyptian int. pharmaceutical industries co.