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03-04-2015, 11:50 AM

1. What Isosorbide Dinitrate tablets are and what they are used for?
Isosorbide Dinitrate belongs to a group of medicines called nitrate vasodilators. These work by relaxing the blood vessels of the heart, reducing the strain on the heart making it easier to pump blood.
Isosorbide Dinitrate tablets may be used to:
relieve the pain and frequency of angina attacks.
help control certain types of heart failure.

2. Before you take Isosorbide Dinitrate tablets
Do not take Isosorbide Dinitrate tablets if you:
are allergic (hypersensitive) to isosorbide dinitrate, isosorbide mononitrate or any of the ingredients in the tablet (see section 6). An allergic reaction may include a rash, itching or difficulty breathing
have any condition where your blood pressure is very low or your blood is not circulating properly (such as shock)
suffer from haemorrhage (problems with bleeding)
are dehydrated due to illness such as diarrhoea or being sick
have heart problems such as heart valve problems, inflammation of the heart surface, build up of fluid under the surface of the heart or progressive heart failure due to long term lung disease
have angina that is caused by an enlarged heart muscle
have raised pressure in your head
have severe anaemia.
Check with your doctor or pharmacist before taking Isosorbide Dinitrate tablets if you:
have glaucoma (increased pressure in the eye)
have any serious damage to your heart (such as after a heart attack or operation)
have been told you suffer from deficiency of an enzyme called glucose 6 phosphate dehydrogenase (G6PD). This condition is sometimes called “Favism” (it is a form of anaemia that is more common in Mediterranean people, attacks may occur after eating certain foods, such as broad beans)
have severe kidney or liver problems
have an underactive thyroid gland
are undernourished as a result of a poor diet
are suffering from hypothermia
have suffered from a head injury or bleeding in the brain.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Especially:
noradrenaline (norepinephrine) – to treat high blood pressure or heart attack
acetylcholine – used in some operations
medicines to treat high blood pressure such as calcium channel blockers (e.g. nifedipine)
tricyclic antidepressants (e.g. amitriptyline)
phenothiazines (e.g. chlorpromazine) – to treat mental illness
histamine – to treat allergic reactions
sildenafil, tadalafil or vardenafil, used to treat male erection dysfunction, should not be taken if taking nitrate preparations such as Isosorbide Dinitrate tablets because a severe and possibly dangerous fall in blood pressure can occur. This would result in collapse, unconsciousness and could be fatal.
Pregnancy and breastfeeding
If you are pregnant, planning to become pregnant or breastfeeding speak to a doctor before taking Isosorbide Dinitrate tablets.
Taking Isosorbide Dinitrate tablets with alcohol
You are advised not to drink alcohol with this medicine.

3. Possible side effects
Like all medicines, Isosorbide Dinitrate tablets can cause side effects, although not everybody gets them.
Contact your doctor immediately if you notice signs of: allergic skin reactions, skin that is red, flaky or peeling (exfoliative dermatitis), severe form of skin rash with flushing, fever, blisters or ulcers (Stevens-Johnson Syndrome) and swelling of the face, lips, tongue or throat (angioedema).
Please tell your doctor or pharmacist if you notice any of the following effects or any not listed:
Very common (occurs in more than 1 in 10 users):
headache (especially when you first start taking Isosorbide Dinitrate tablets).
Common (occurs in less than 1 in 10 users):
a decrease in blood pressure, dizziness or faintness when standing up due to low blood pressure, a racing heart beat, drowsiness, dizziness and weakness may also occur (especially when Isosorbide Dinitrate tablets are used for the first time or when your dose is increased).
swelling of the hands, ankles or feet.
Uncommon (occurs in less than 1 in 100 users):
feeling or being sick.
worsening of angina due to very low blood pressure.
collapsing with slow or irregular heart beat and fainting.
Very rare (occurs in less than 1 in 10, 000 users):
shallow and slow breathing causing low oxygen in the blood and a risk of heart attack in patients with heart disease.
increased pressure in the eye (angle closure glaucoma).
a type of tumour that affects the pituitary, may cause headaches or vision problems.