Medical Videos
06-05-2009, 09:40 AM
Tubulo interstitial nephritis
Def It is an inflammation with infiltration by inflammatory cells in interstitial tissues with tubular damage of tubules but the glomeruli are spared.
˛Late extension of fibrosis increased interestitial fibrous tissue + hyalinzed glomeruli
N.B. pyelonephritis:
Pathologically, it is similar to interstitial nephritis but caused by organisms(infection).
Acute interstitial nephritis: (drug induced hypersensitivity nephritis)
-causes:
e.g. acute hypersensitivity nephritis caused by Ampicillin, sulpha, cephalosporins, rifampicin , frusemide,allopurinol&NSAID.
-Diagnosis: 1-acute renal failure.
2- manifest. Of allergy (fever - rash), arthralgia.
3- urine showing eosinophiluria& eosinophilia.
Ttt stop drugs ± short term steroid ?!.
Dialysis for A.R.F.
Causes:
-NSAID. –sickle cell anaemia.
-Lead. –Irradiation.
-Gouty nephropathy. –chronic pyelonephritis.
-Diagnosis:
-cause. – manifestation of CRF.
-usually there is polyuria due to defects in urine concentration.
Protinuria usually < 1 gm.
-salt wasting may occur.
-ttt:- -of cause.
-treated as C.R.F.
Source: Internal Medicine Book of Dr.Osama Mahmoud (Ain Shams University)
Def It is an inflammation with infiltration by inflammatory cells in interstitial tissues with tubular damage of tubules but the glomeruli are spared.
˛Late extension of fibrosis increased interestitial fibrous tissue + hyalinzed glomeruli
N.B. pyelonephritis:
Pathologically, it is similar to interstitial nephritis but caused by organisms(infection).
Acute interstitial nephritis: (drug induced hypersensitivity nephritis)
-causes:
e.g. acute hypersensitivity nephritis caused by Ampicillin, sulpha, cephalosporins, rifampicin , frusemide,allopurinol&NSAID.
-Diagnosis: 1-acute renal failure.
2- manifest. Of allergy (fever - rash), arthralgia.
3- urine showing eosinophiluria& eosinophilia.
Ttt stop drugs ± short term steroid ?!.
Dialysis for A.R.F.
Causes:
-NSAID. –sickle cell anaemia.
-Lead. –Irradiation.
-Gouty nephropathy. –chronic pyelonephritis.
-Diagnosis:
-cause. – manifestation of CRF.
-usually there is polyuria due to defects in urine concentration.
Protinuria usually < 1 gm.
-salt wasting may occur.
-ttt:- -of cause.
-treated as C.R.F.
Source: Internal Medicine Book of Dr.Osama Mahmoud (Ain Shams University)