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06-05-2009, 09:36 AM
Membranoproliferative (mesangiocapillary)

Causes:
Idiopathic © Hepatitis C © B ©infective endocarditis

Investig:
1 Serum C3 ¯ (hypocomplementemia) MCQ
1 Biopsy :
Light membrane thickened.
Åcell ¯ (esp. mesangio.)
E/M details type I subendoth. Deposits.
Type II dense deposits intra
Membranous.
immunoflurescence C3 - Ig G.

& In type II there is a nephritic factor (Ig G activate c).
& Prognosis both types bad prognosis, type II recurs in
transplanted kid.

C/P: Some cases presented with

nephritic or nephrotic haematuria
-mixed picture are common as :
hypertension - haematuria + heavy proteinuria

nephritic nephrotic
ttt : steroids - cytotoxic drugs ( no definite value) – antiplatlet


G.N. with ¯ C.
Membranoproliferative - poststreptococcal - SLE

Source: Internal Medicine Book of Dr.Osama Mahmoud (Ain Shams University)