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06-05-2009, 09:35 AM
Good pasture $


It is an autoimm. Disease due to circulating antiglomerular basement membrane antibody.

C/P
Nephritic S within wks -or ms renal failure.
Haemoptysis as there is similarity between glomerular B.M. & alveolar membrane.
Investig
Ab against G.B.M. Biopsy


Light : crescents E/M Immunoflorescent

details no immune complex
The crescent as it is an autoimmune
Formed of cells+PNL linear deposits of Ig G
Usually present
ttt of good pasture $: steroids + cytotoxic drugs.
Plasmapharesis
A- 1-Infection nephritic = post inf. G
2-Arthropathy nephritic + lupus nephritis.
3-Haemoptysis + renal impairment G.Pasture $,T.B.or wegener’s granuloma
B- in ttt of rapidly progreesive G.N, usually we use pulsed steroid therapy.

Source: Internal Medicine Book of Dr.Osama Mahmoud (Ain Shams University)