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06-05-2009, 09:32 AM
Diabetic nephrophropathy


♣It is not a glomerulonephritis but is considered to be glomerulopathy.
♣It Occurs in type I, II, but it is common in type I due to long natural history
♣It is related to control of Diabetes and also to duration (10-15yrs).
♣Usually it is a part of Diabetic triopathy :

retinopathy Nephropathy Neuropathy

C/P D.M. + nephrotic $ C.R. F.
Early diagnosis by appearance of micro albuminuria.
Micro glomerulosclerosis (there is thickening of B.M.)
Sonar normal or large kidney size.
ttt
Control of bl. sugar prevent the early hyperfiltration
ACE inhibitor vasodil. Of efferent arteriole.
arteriole intra glomerular pressure
process of glomerulosclerosis
post pond C R F
N.B : Diabetic nephropathy diagnosis does not depend upon
renal biopsy

N.B. (problems)
Pt with B nephrotic$=B nephropathy FSGS- member.prolif)
G. L. adenopathy nephrotic $
AIDS lymphoma
FSGS minimal L.
Fever then nephrotic

FMF chr. Malaria (malarial nephropathy)

abd. Pain huge spleen ++
Arthropathy nephrotic $
SLE Rheumatoid amyloidosis kid.
nephrotic $ : drugs:NSAID
penicillamine gold
Pt with D.M. nephrotic $ = diabetic nephrop

Source: Internal Medicine Book of Dr.Osama Mahmoud (Ain Shams University)