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06-05-2009, 09:31 AM
Focal & Segmental glomerulosclerosis
Common in children
Adult also can be affected
Steroid resistant
It can lead to CRF.

Causes:

1- Idiopathic 1 ry
2- AIDS associated nephropathy
3- Heroin nephropathy. 2ry
4-Reflux nephropathy.
5-B

C/P: nephrotic $

Micro:




Light: almost normal

E M focal = some glomeruli are affected.
Segmental= part of each glomerus is affected.
Glomerulosclerosis(partial or total replacement
of glomerulus by hyaline material)

Immunoflorescence Ig M C3.

Poor response to steroids or cytotoxic drugs

Source: Internal Medicine Book of Dr.Osama Mahmoud (Ain Shams University)