Medical Videos
06-05-2009, 09:31 AM
Focal & Segmental glomerulosclerosis
Common in children
Adult also can be affected
Steroid resistant
It can lead to CRF.
Causes:
1- Idiopathic 1 ry
2- AIDS associated nephropathy
3- Heroin nephropathy. 2ry
4-Reflux nephropathy.
5-B
C/P: nephrotic $
Micro:
Light: almost normal
E M focal = some glomeruli are affected.
Segmental= part of each glomerus is affected.
Glomerulosclerosis(partial or total replacement
of glomerulus by hyaline material)
Immunoflorescence Ig M C3.
Poor response to steroids or cytotoxic drugs
Source: Internal Medicine Book of Dr.Osama Mahmoud (Ain Shams University)
Common in children
Adult also can be affected
Steroid resistant
It can lead to CRF.
Causes:
1- Idiopathic 1 ry
2- AIDS associated nephropathy
3- Heroin nephropathy. 2ry
4-Reflux nephropathy.
5-B
C/P: nephrotic $
Micro:
Light: almost normal
E M focal = some glomeruli are affected.
Segmental= part of each glomerus is affected.
Glomerulosclerosis(partial or total replacement
of glomerulus by hyaline material)
Immunoflorescence Ig M C3.
Poor response to steroids or cytotoxic drugs
Source: Internal Medicine Book of Dr.Osama Mahmoud (Ain Shams University)