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03-18-2009, 10:58 AM
Histiocytosis X

(eosinophilic granuloma of the lung)
Def. Systemic disorders characterized by infiltration of tissue by non malignant histiocytes and eosinophils with fibrosis it may be localized to bone or lung or disseminated.
Pathology:
Proliferating histiocytes show cytoplasmic inclusions the so called x bodies.
C/P
• Cough • dyspnea • fever
• D.I. • Exophthalmous
Investigation
• Honey comp, restrictive pulmonary fibrosis, biopsy.
• Also bronchial lavage ΰ X bodies.
• Bone X ray ΰbone defect.
Treatment
• Steroids • Radiotherapy
N.B. Eosinophi1ic granuloma of lung and bone including:
• Letterer siwe disease
• Hand Schuller Chrictian syndrome

Source: Internal Medicine Book of Dr.Osama Mahmoud (Ain Shams University)