Syphilis aetiology:
A. Causative organism: treponema pallidum (spirochete).
B. Mode of infection:
1) Sexual route: sexual intercourse.
2) Non-sexual route: materno-fetal (placental).
C. Predisposing factors: multiple sexual partners.
Syphilis diagnosis:
Primary syphilis: (incubation period= 2- 6 weeks)
– Chancre: (the commonest site is cervix)
– Single, punched out & painless
– Heals spontaneously within 4 weeks.
– Inguinal lymphadenopathy.
Secondary syphilis: (incubation period= 2- 6 months after the primary)
– Generalized maculopapular skin rash.
– Mucous patches and condylomata lata.
– Generalized lymphadenopathy especially epitrochlear lymph nodes.
Tertiary syphilis: (incubation period= 2- 20 years)
– Gumma.
– Cardiovascular lesions especially aortic regurge.
– Neurosyphilis: tabes dorsalis.
Syphilis investigations:
♦♦♦ Fluorescent treponemal antibody (FTA) test is the most sensitive & specific test for $.
♦♦♦ For obvious lesions: biopsy to detect syphilitic granulation tissue & EAO.
♦♦♦ For non-obvious lesions: (serological tests)
– Non-specific e.g. Wasserman reaction.
– Specific: e.g. TPI (treponema pallidum immobilization test).
Syphilis treatment:
A. Prevention: prevention of STD.
B. Active treatment:
– Benzathine penicillin: 2.4 million IU / week for 3 weeks.
– Side effects: Jarisch- Hexaheimer reaction.
C. Treatment during pregnancy:
– Penicillin: if the patient is sensitive, desensitization is done.
– Tetracycline & erythromycin aren’t used.
Syphilis videos:
Symptoms of Syphilis video
This week with Dr. Dominic Rowley, we are discussing it and the resurgence of the infection in recent years. See below for an overview of points covered in this video. 0:19 – What is it? 0:32 – How is it transmitted? 0:50 – How common is it ? 1:22 – How do you know if you have it? 3:51 – How is it diagnosed? 4:06 – How is it treated? 5:03 – If you get treated for it, do you always have it? 5:50 – How can you get checked?
Diagnosis, treatment, and prevention of syphilis | Infectious diseases | NCLEX-RN | Khan Academy video
What is syphilis? | Infectious diseases | NCLEX-RN | Khan Academy video
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Syphilis|microbiology|-animated quick review video
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum.[1] The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary). The primary stage classically presents with a single chancre (a firm, painless, non-itchy skin ulceration) but there may be multiple sores. In secondary syphilis a diffuse rash occurs, which frequently involves the palms of the hands and soles of the feet. There may also be sores in the mouth or vagina. In latent syphilis, which can last for years, there are few or no symptoms.[2] In tertiary syphilis there are gummas (soft non-cancerous growths), neurological, or heart symptoms.[3] Syphilis has been known as “the great imitator” as it may cause symptoms similar to many other diseases.
Syphilis PPT (power point presentations):
Syphillis SEMINAR PRESENTATION SYPHILIS MODERATOR DR.C.M. KULDEEP PPT
STRUCTURE AND PHYSIOLOGYOF TREPONEMES, Pathogenesis, Classification of Syphilis, PRIMARY SYPHILIS, SECONDARY SYPHILIS, TERTIARY SYPHILIS, Late benign syphilis, Cardiovascular syphilis, Neurosyphilis, Lab diagnosis of syphilis
SYPHILIS – TREPONEMA PALLIDUM Dr. R. Someshwaran, MBBS, MD., Assistant professor, Dept. of Microbiology, KFMS&R PPT
SYPHILIC THEORY CLASS PPT – SECOND MBBS STUDENTS – UNDERGRADUATE STUDENTS – MEDICAL COLLEGE – POWERPOINT