A. Causative organism: treponema pallidum (spirochete).
B. Mode of infection:
1) Sexual route: sexual intercourse.
2) Non-sexual route: materno-fetal (placental).
C. Predisposing factors: multiple sexual partners.
Primary syphilis: (incubation period= 2- 6 weeks)
– Chancre: (the commonest site is cervix)
– Single, punched out & painless
– Heals spontaneously within 4 weeks.
– Inguinal lymphadenopathy.
Secondary syphilis: (incubation period= 2- 6 months after the primary)
– Generalized maculopapular skin rash.
– Mucous patches and condylomata lata.
– Generalized lymphadenopathy especially epitrochlear lymph nodes.
Tertiary syphilis: (incubation period= 2- 20 years)
– Gumma.
– Cardiovascular lesions especially aortic regurge.
– Neurosyphilis: tabes dorsalis.


♦♦♦ Fluorescent treponemal antibody (FTA) test is the most sensitive & specific test for $.
♦♦♦ For obvious lesions: biopsy to detect syphilitic granulation tissue & EAO.
♦♦♦ For non-obvious lesions: (serological tests)
– Non-specific e.g. Wasserman reaction.
– Specific: e.g. TPI (treponema pallidum immobilization test).
A. Prevention: prevention of STD.
B. Active treatment:
– Benzathine penicillin: 2.4 million IU / week for 3 weeks.
– Side effects: Jarisch- Hexaheimer reaction.
C. Treatment during pregnancy:
– Penicillin: if the patient is sensitive, desensitization is done.
– Tetracycline & erythromycin aren’t used.

What is Syphilis? | What are the Symptoms of Syphilis?

This week with Dr. Dominic Rowley, we are discussing syphilis and the resurgence of the infection in recent years. See below for an overview of points covered in this video. 0:19 – What is syphilis? 0:32 – How is syphilis transmitted? 0:50 – How common is syphilis? 1:22 – How do you know if you have syphilis? 3:51 – How is syphilis diagnosed? 4:06 – How is syphilis treated? 5:03 – If you get treated for syphilis, do you always have it? 5:50 – How can you get checked?

Diagnosis, treatment, and prevention of syphilis | Infectious diseases | NCLEX-RN | Khan Academy

What is syphilis? | Infectious diseases | NCLEX-RN | Khan Academy

About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We’ve also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.

Syphilis|microbiology|-animated quick review

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum.[1] The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary). The primary stage classically presents with a single chancre (a firm, painless, non-itchy skin ulceration) but there may be multiple sores. In secondary syphilis a diffuse rash occurs, which frequently involves the palms of the hands and soles of the feet. There may also be sores in the mouth or vagina. In latent syphilis, which can last for years, there are few or no symptoms.[2] In tertiary syphilis there are gummas (soft non-cancerous growths), neurological, or heart symptoms.[3] Syphilis has been known as “the great imitator” as it may cause symptoms similar to many other diseases


STRUCTURE AND PHYSIOLOGY OF TREPONEMES, Pathogenesis, Classification of Syphilis, PRIMARY SYPHILIS, SECONDARY SYPHILIS, TERTIARY SYPHILIS, Late benign syphilis, Cardiovascular syphilis, Neurosyphilis, Lab diagnosis of syphilis

SYPHILIS – TREPONEMA PALLIDUM Dr. R. Someshwaran, MBBS, MD., Assistant professor, Dept. of Microbiology, KFMS&R


Syphilis basics


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