Cipazole forte tablet Composition:
Each tablet contains:
Secnidazole 1 gm
Cipazole forte tablet Properties and Mechanism of Action:
Cipazole forte contains Secnidazole which belongs to Nitroimidazole derivatives.
It is an anti-protozoal drug which has pharmacological activity against Intestinal and
Hepatic Amebiasis, Giardiasis and Trichomonas vaginalis.
** Recent studies showed that a single 1 gm oral dose of Secnidazole is effective to
cure bacterial vaginosis associated with Gardnerella vaginalis.
Cipazole forte tablet Indications and Usage:
Cipazole forte is indicated for the treatment of:
– Intestinal Amebiasis.
– Hepatic Amebiasis.
– Giardiasis.
– Urethritis and vaginitis due to Trichomonas vaginalis.
Cipazole forte tablet Contraindications:
Cipazole forte is contraindicated in:
– Patients with known hypersensitivity to Imidazole derivatives.
– Pregnancy and Lactation.
Cipazole forte tablet Side Effects:
– Digestive disorders with abdominal pain, change in taste, glossitis, stomatitis.
– Urticaria, moderate leukopenia, reversible upon withdrawal of treatment.
Cipazole forte tablet Drug-Drug Interactions:
Alcoholic drinks and alcohol containing medicines should be avoided during
Secnidazole treatment.
Cipazole forte tablet Precautions:
• Do not administer to patients with a history of blood dyscrasias.
Cipazole forte tablet Dosage and Administration:
– Acute Intestinal Amebiasis: One-day treatment
Adults: 2 gm (2 tablets) as a single dose.
Children: 30 mgl kg as a single or several divided doses.
– Hepatic Amebiasis: Five-day treatment;
Daily dose:
Adults: 1.5 gm (one and a half tablets) as a single dose.
Children: 30 mgl kg as a single or several divided doses.
– Urogenital Trichomoniasis:
2 gm (2 tablets) as a single dose.
* The dose preferably be taken during a meal.
Cipazole forte tablet How Supplied:
A box containing one blister of 2 tablets.
Cipazole forte tablet Produced by :
SIGMA Pharrnaceutical industries -Egypt- S.A.E.
Treatment of amoebiasis & giardiasis PPT power point presentation :
1. TREATMENT OF AMOEBIASIS & GIARDIASIS
2. It is the infection caused by protozoa Entamoeba histolytica. It is usually transmitted by faecal transmission of food & water. Mostly present in the areas with poor environmental sanitation. AMOEBIASIS
3. Classification Of Drugs Tissue Amoebicides A. For both Intestinal & Extraintestinal Amoebiasis: i. Nitroimidazoles: Metronidazole, Tinidazole, Secnidazole, Ornidazole, Satranidazole ii. Alkaloids: Emetine, Dehydroemetine B. For extraintestinal amoebiasis only: Chloroquine Luminal Amoebicides A. Amide: Diloxanide furoate, Nitazoxanide B. 8-Hydroxyquinolines: Quiniodochlor, Diiodohydroxyquin C. Antibiotics: Tetracyclins
4. METRONIDAZOLE It has broad spectrum cidal activity against protozoa including Giardia lamblia & Amoeba. Many anaerobic bacteria are sensitive. Anaerobic bacteria & G. lamblia also can develop metronidazole resistance, but this is a clinical problem only in the case of H.pylori.
5. Metronidazole is selectively toxic to anaerobic microorganisms. Af ter entering the cell by dif fusion, its nitro gp. is reduced by certain redox proteins operative only in anaerobic microbes to highly reactive nitro radical which exerts cytotoxicity. The nitro radical of metronidazole acts as an electron sink which competes with the biological electron acceptors of the anaerobic organism for the electrons generated by the pyruvate:ferredoxin oxidoreductase(PFOR) enzyme pathway of pyruvate oxidation. The energy metabolism of anaerobes, is thus, disrupted.
6. Aerobic environment attenuates cytotoxicity of metronidazole by inhibiting its reductive activation. Anaerobes which develop metronidazole resistance become deficient in the mechanism that generates the reactive nitro radical from it.
7. PHARMACOKINETICS Metronidazole is almost completely absorbed from the small intestines; little unabsorbed drug reaches the colon. It is widely distributed in the body, attaining therapeutic concentration in vaginal secretion, semen, saliva & CSF. It is metabolized in liver primarily by oxidation & glucoronide conjugation & excreted in urine. Plasma t-half is 8hrs.
Cipazole forte tablet