Agnes Fogo, MD
Renal sarcoidosis is manifest by multiple sharply delineated non-necrotizing granulomas with frequent epithelioid-type multinucleated giant cells with accompanying interstitial fibrosis and lymphoplasmacytic interstitial infiltrate, as illustrated here. (Jones' Silver Stain, original magnification X100).
The well delineated non-necrotizing granulomas typical of sarcoidosis are illustrated here, with adjacent tubulointerstitial fibrosis. Giant cells are evident. (Jones Silver Stain, original magnification X200).
The large giant cells comprising the non-necrotizing granulomas typical of renal sarcoidosis are evident in this biopsy, with surrounding lymphoplasmacytic interstitial infiltrate and early tubulointerstitial fibrosis. (Jones Silver Stain, original magnification X200).
A well-delineated granuloma is seen surrounding an intact glomerulus in this case of renal sarcoidosis. There are numerous giant cells and surrounding lymphocytes and plasma cells with early interstitial fibrosis. (Hematoxylin and Eosin, original magnification X200).
The multinucleated giant cell typical of sarcoidosis is shown under high magnification in this biopsy. (Periodic Acid Schiff, original magnification X400).