Admin
02-12-2009, 10:07 AM
Collapsing Glomerulopathy
Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman
http://www2.ajkd.org/ajkd/atlas/38/5/big/fig1.jpg
Fig 1. Collapsing glomerulopathy is characterized by collapse of the glomerular tuft with marked proliferation of overlying glomerular visceral epithelial cells, often with prominent protein droplets, as shown here. There is typically accompanying disproportionate tubular injury in more advanced cases, frequently with microcystic change. (Jones' silver stain, X400).
http://www2.ajkd.org/ajkd/atlas/38/5/big/fig2.jpg
Fig 2. The collapsing pattern in collapsing glomerulopathy is evident here, with an accentuation of each lobule due to the collapse of the tufts. There is also overlying glomerular visceral epithelial cells. Occasional intercapillary foam cells are also evident. The light microscopic appearance is similar in HIV-associated nephropathy. Microcystic tubular injury is shown on the edge of this slide. (Jones' silver stain, X400).
http://www2.ajkd.org/ajkd/atlas/38/5/big/fig3.jpg
Fig 3. In idiopathic collapsing glomerulopathy, the collapse of the tufts is evident by electron microscopy, and there is foot process effacement with extensive microvillus change. This is associated with loss of differentiation markers of the glomerular visceral epithelial cells. In idiopathic collapsing glomerulopathy there are no reticular aggregates, in contrast to their frequent presence in cases of HIV nephropathy. (Transmission electron microscopy, X6000).
Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman
http://www2.ajkd.org/ajkd/atlas/38/5/big/fig1.jpg
Fig 1. Collapsing glomerulopathy is characterized by collapse of the glomerular tuft with marked proliferation of overlying glomerular visceral epithelial cells, often with prominent protein droplets, as shown here. There is typically accompanying disproportionate tubular injury in more advanced cases, frequently with microcystic change. (Jones' silver stain, X400).
http://www2.ajkd.org/ajkd/atlas/38/5/big/fig2.jpg
Fig 2. The collapsing pattern in collapsing glomerulopathy is evident here, with an accentuation of each lobule due to the collapse of the tufts. There is also overlying glomerular visceral epithelial cells. Occasional intercapillary foam cells are also evident. The light microscopic appearance is similar in HIV-associated nephropathy. Microcystic tubular injury is shown on the edge of this slide. (Jones' silver stain, X400).
http://www2.ajkd.org/ajkd/atlas/38/5/big/fig3.jpg
Fig 3. In idiopathic collapsing glomerulopathy, the collapse of the tufts is evident by electron microscopy, and there is foot process effacement with extensive microvillus change. This is associated with loss of differentiation markers of the glomerular visceral epithelial cells. In idiopathic collapsing glomerulopathy there are no reticular aggregates, in contrast to their frequent presence in cases of HIV nephropathy. (Transmission electron microscopy, X6000).