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01-26-2009, 08:38 AM
Multifocal Ductal Carcinoma of the Breast
Click on Images for Enlarged View Clinical History: 60-year-old asymptomatic female for screening mammogram.
Findings:Cluster of pathologic calcifications with minimal change over time.
http://www.uhrad.com/mamarc/mam005a.gif (http://www.uhrad.com/mamarc/mam005a.jpg)
9/22/92
Cluster of multiple indeterminate calcifications in mid portion of left breast.
http://www.uhrad.com/mamarc/mam005b.gif (http://www.uhrad.com/mamarc/mam005b.jpg)
6/3/94
Cluster of heterogenous multiple calcifications, slightly better defined than 9/25/92.
http://www.uhrad.com/mamarc/mam005c.gif (http://www.uhrad.com/mamarc/mam005c.jpg)
6/28/95
Calcifications now pleomorphic and increased in number since 6/3/94. Worrisome for carcinoma.
http://www.uhrad.com/mamarc/mam005d.gif (http://www.uhrad.com/mamarc/mam005d.jpg)
7/05/95
Pleomorphic calcifications, again worrisome.
http://www.uhrad.com/mamarc/mam005e.gif (http://www.uhrad.com/mamarc/mam005e.jpg)
8/31/95
Needle localization biopsy sample containing calcifications.
Pathology: Multifocal ductal carcinoma in situ, micropapillary and cribriform types - low grade. Focal lobular carcinoma in situ. Fibrocystic disease with atypical ductal epithelial hyperplasia and papillomatosis.
Diagnosis: Multifocal ductal carcinoma in situ.
Discussion: Worrisome calcifications should be biopsied, regardless of stability over time.
Submitted by:
Anne H. Nicklas, M.D>
Sutek Lie, M.D.
Click on Images for Enlarged View Clinical History: 60-year-old asymptomatic female for screening mammogram.
Findings:Cluster of pathologic calcifications with minimal change over time.
http://www.uhrad.com/mamarc/mam005a.gif (http://www.uhrad.com/mamarc/mam005a.jpg)
9/22/92
Cluster of multiple indeterminate calcifications in mid portion of left breast.
http://www.uhrad.com/mamarc/mam005b.gif (http://www.uhrad.com/mamarc/mam005b.jpg)
6/3/94
Cluster of heterogenous multiple calcifications, slightly better defined than 9/25/92.
http://www.uhrad.com/mamarc/mam005c.gif (http://www.uhrad.com/mamarc/mam005c.jpg)
6/28/95
Calcifications now pleomorphic and increased in number since 6/3/94. Worrisome for carcinoma.
http://www.uhrad.com/mamarc/mam005d.gif (http://www.uhrad.com/mamarc/mam005d.jpg)
7/05/95
Pleomorphic calcifications, again worrisome.
http://www.uhrad.com/mamarc/mam005e.gif (http://www.uhrad.com/mamarc/mam005e.jpg)
8/31/95
Needle localization biopsy sample containing calcifications.
Pathology: Multifocal ductal carcinoma in situ, micropapillary and cribriform types - low grade. Focal lobular carcinoma in situ. Fibrocystic disease with atypical ductal epithelial hyperplasia and papillomatosis.
Diagnosis: Multifocal ductal carcinoma in situ.
Discussion: Worrisome calcifications should be biopsied, regardless of stability over time.
Submitted by:
Anne H. Nicklas, M.D>
Sutek Lie, M.D.